Abstract
THE introduction of quantitative methods to measure the rate of phagocytosis of bacteria by the reticulo-endothelial system in vivo has revived interest in the examination of the relationship between bacterial virulence and phagocytosis1–3. Although recent investigations have shown no correlation between the rate of phagocytosis of different bacterial species and their virulence in mice4,5, a rather different relationship has been noted for different bacteria of the same species. The rate of phagocytosis by reticulo-endothelial cells of an avirulent rough strain of Salmonella typhi is much greater than that of the virulent smooth form of the same micro-organism6. Jenkin and Rowley7 have reported that virulent strains of Salmonella are phagocytosed by reticulo-endothelial system slower than non-virulent ones.
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References
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BIOZZI, G., LE MINOR, L., STIFFEL, C. et al. Correlation between Virulence and Phagocytosis of Genetic Recombinant between Escherichia coli and Salmonella typhimurium. Nature 202, 819–820 (1964). https://doi.org/10.1038/202819b0
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DOI: https://doi.org/10.1038/202819b0
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