Abstract
THE well-known stimulatory action of 2-phenylisopropylamine (amphetamine) and, more recently, the use of 2-phenylisopropylhydrazine as a psychic energizer1, prompted us to investigate the pharmacology of N-(2-phenylisopropyl)hydroxylamine (PIH) and its O-methyl ether (PIHE). Little has been published concerning the pharmacology of N-substituted hydroxylamines although Jones and Major2 examined the action of a series of hydroxylamino analogues of certain biologically active amines and Lewin3 commented on the toxicity of N-phenylhydroxylamine.
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References
Biel, J. H., Drukker, A. E., Shore, P. A., Spector, S., and Brodie, B. B., J. Amer. Chem. Soc., 80, 1519 (1958).
Jones, L. W., and Major, R. T., J. Amer. Chem. Soc., 49, 1527 (1927).
Lewin, L. Frankel, Arzneimittel-Synthese, 78 (Julius Springer, Berlin, 1921).
Vavon, G., and Crajeinovic, M., Bull. Soc. Chim. (4), 43, 231 (1928).
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Whittle, B. A., and Young, E. P. H., J. Medicinal Chem., 6, 378 (1963).
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BENINGTON, F., MORIN, R. & CLARK, L. Pharmacological Activity of Phenylisopropylhydroxylamine and its O-Methyl Ether. Nature 202, 813 (1964). https://doi.org/10.1038/202813a0
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DOI: https://doi.org/10.1038/202813a0
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