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Interrelations of Human Serum Protein Fractions in Health and Disease


DURING a recent quantitative investigation of the human serum proteins1, a preliminary report was published of statistical associations between protein fractions of healthy subjects in the course of fluctuations within the normal range2. The results were sufficiently interesting to warrant extension of the material to examine the possible effects of a variety of disease processes on these interrelations. This article reports some results which were obtained from a series of patients with carcinoma, cirrhosis of the liver, myocardial infarction, pneumonia, and rheumatoid arthritis, and compares them with results drawn from normal persons in good health and also in pregnancy.

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BRACKENRIDGE, C. Interrelations of Human Serum Protein Fractions in Health and Disease. Nature 202, 710–711 (1964).

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