Cell Surface Effects of Phytohæmagglutinin

Article metrics


IT has been suggested that the lymphocyte-stimulating effects of phytohæmagglutinin (PHA) may be mediated by a cell surface reaction, thus accounting for the agglutination of PHA-treated lymphocytes1. Surface binding of PHA would, in all likelihood, change the cell surface charge density as estimated by cell electrophoresis. The experiments described here were designed to investigate this possibility and, accordingly, lymphoid cells were collected from a variety of sources and their electrophoretic mobilities determined before and after exposure to PHA.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Hirschhorn, K., Bach, F., Kolodny, R. L., Firschein, I. L., and Hashem, N., Science, 142, 1185 (1963).

  2. 2

    Vassar, P. S., Taylor, H. E., and Culling, C. F. A., Nature, 200, 691 (1963).

  3. 3

    Vassar, P. S., Lab. Invest., 12, 1072 (1963).

  4. 4

    Hirschhorn, K., Kolodny, R. L., Hashem, N., and Bach, F., Lancet, ii, 305 (1963).

  5. 5

    Cook, G. M. W., Seaman, G. V. F., and Weiss, L., Cancer Res., 23, 1813 (1963).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

VASSAR, P., CULLING, C. Cell Surface Effects of Phytohæmagglutinin. Nature 202, 610–611 (1964) doi:10.1038/202610a0

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.