Cell Surface Effects of Phytohæmagglutinin

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Abstract

IT has been suggested that the lymphocyte-stimulating effects of phytohæmagglutinin (PHA) may be mediated by a cell surface reaction, thus accounting for the agglutination of PHA-treated lymphocytes1. Surface binding of PHA would, in all likelihood, change the cell surface charge density as estimated by cell electrophoresis. The experiments described here were designed to investigate this possibility and, accordingly, lymphoid cells were collected from a variety of sources and their electrophoretic mobilities determined before and after exposure to PHA.

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References

  1. 1

    Hirschhorn, K., Bach, F., Kolodny, R. L., Firschein, I. L., and Hashem, N., Science, 142, 1185 (1963).

  2. 2

    Vassar, P. S., Taylor, H. E., and Culling, C. F. A., Nature, 200, 691 (1963).

  3. 3

    Vassar, P. S., Lab. Invest., 12, 1072 (1963).

  4. 4

    Hirschhorn, K., Kolodny, R. L., Hashem, N., and Bach, F., Lancet, ii, 305 (1963).

  5. 5

    Cook, G. M. W., Seaman, G. V. F., and Weiss, L., Cancer Res., 23, 1813 (1963).

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VASSAR, P., CULLING, C. Cell Surface Effects of Phytohæmagglutinin. Nature 202, 610–611 (1964) doi:10.1038/202610a0

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