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Effect of Aromatic Groups on the Radiation Stability of Glycosides


IT has already been shown1,2 that, when solid glycosides or disaccharides are exposed to γ-radiation, the main reaction is scission of the glycosidic bond to form a sugar and, presumably, the corresponding alcohol. We have found that acid formation accompanies the production of glucose during γ-radiation of solid methyl α-D-glucopyranoside. From the linear yield-dose curves of these products, we find initial G(glucose) 2.33 and G(acid) 1.45. From infra-red investigations, using potassium bromide disks, it would appear that the acid is formed directly in the solid and not merely after dissolution of the irradiated crystal in water.

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PHILLIPS, G., BLOUIN, F. & ARTHUR, J. Effect of Aromatic Groups on the Radiation Stability of Glycosides. Nature 202, 1328–1329 (1964).

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