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Failure to propagate a Lactic Dehydrogenase-elevating Agent from Mice Tumours in Mice Embryo Cultures


MANY tumours of mice contain a virus-like agent which causes a sharp and continued elevation of the activity of lactic dehydrogenase (LDH) in serum or plasma of infected host mice1–3. The so-called LDH agent (Riley) is usually maintained and propagated in living mice. To facilitate further investigation, especially of its viral nature, it seemed desirable to adapt and propagate the LDH agent in cell cultures under established and known conditions. The few results concerning this problem are contradictory4–6.

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GEORGII, A., LENZ, I. Failure to propagate a Lactic Dehydrogenase-elevating Agent from Mice Tumours in Mice Embryo Cultures. Nature 202, 1228–1229 (1964).

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