SEVERAL investigators have attempted to prevent induction of tumours in animals infected by oncogenic viruses using immunization procedures during the latent period, that is, before the appearance of visible (palpable) tumours. In these experiments, virus-infected animals were inoculated during the latent period by live or killed tumour cells or by their components. Zilber and Baidakova1 indicated that the Bittner mammary tumour development in immunized mice could not be prevented although the duration of the latent period was longer. Goldner et al.2 failed to immunize SV40-infected hamsters by ‘Björklund-type’ tumour antigen; some stimulation effect on the tumour growth in such animals was obtained.
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DEICHMAN, G., KLUCHAREVA, T. Prevention of Tumour Induction in SV40-infected Hamsters. Nature 202, 1126–1128 (1964). https://doi.org/10.1038/2021126b0
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