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Ingestion of DDT and Liver Glucose-6-phosphate Dehydrogenase Activity


THE histological changes produced by the ingestion of DDT have been described in numerous publications, there being some controversy over the minimum dietary level producing detectable changes1. There is, however, little knowledge of the biochemical processes involved in the toxicological action of this compound. In an effort to obtain some understanding of these changes investigations are in progress in our laboratory of the tissue enzymes affected by the ingestion of DDT.

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  1. Hayes, W. J., DDT, edit. by Muller, Paul, 2, 106 (Birkhausen Verlag, Basle, 1959).

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  2. Bubl, Edward C., and Butts, Joseph S., J. Nutrition, 70, 211 (1960).

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  3. Knoche, Ingo, and Hartmann, Fritz, Biochem. Z., 334, 269 (1961).

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  4. Willmer, J. S., Canad. J. Biochem. and Physiol., 38, 1449 (1960).

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TINSLEY, I. Ingestion of DDT and Liver Glucose-6-phosphate Dehydrogenase Activity. Nature 202, 1113–1114 (1964).

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