Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Enzymatic Regulation of Trehalose and Glycogen Synthesis in the Fat Body of an Insect


INSECTS can maintain their blood trehalose at levels which are characteristic of the species and stage of development1. In the silkworm, Bombyx mori, the blood trehalose-level returns rapidly to normal after being experimentally altered2. In saturniid silkmoth pupæ, superficial injury is followed by accelerated carbohydrate turnover and net conversion of glycogen to trehalose, which afterwards returns to its normal level3. We have now discovered characteristics of the enzymes of trehalose and glycogen synthesis in silkmoths which may help to explain these regulatory phenomena.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout


  1. Wyatt, G. R., Ann. Rev. Entomol., 6, 75 (1961).

    Article  CAS  Google Scholar 

  2. Saito, S., J. Insect. Physiol., 9, 509 (1963).

    Article  CAS  Google Scholar 

  3. Wyatt, G. R., Fed. Proc., 20, 81 (1961). Insect Physiology (twenty-third Biol. Colloq., Oregon State Univ., Corvallis, 1962), 23 (1963).

    Google Scholar 

  4. Candy, D. J., and Kilby, B. A., Biochem. J., 78, 531 (1960).

    Article  Google Scholar 

  5. Cabib, E., and Leloir, L. F., J. Biol. Chem., 231, 259 (1958).

    CAS  PubMed  Google Scholar 

  6. Vardanis, A., Biochim. Biophys. Acta, 73, 565 (1963).

    Article  CAS  Google Scholar 

  7. Leloir, L. F., and Goldemberg, S. H., J. Biol. Chem., 235, 919 (1960).

    CAS  PubMed  Google Scholar 

  8. Stevenson, E., and Wyatt, G. R., Arch. Biochem. Biophys., 99, 65 (1962).

    Article  CAS  Google Scholar 

  9. Stevenson, E., and Wyatt, G. R., Fed. Proc., 22, 298 (1963).

    Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

MURPHY, T., WYATT, G. Enzymatic Regulation of Trehalose and Glycogen Synthesis in the Fat Body of an Insect. Nature 202, 1112–1113 (1964).

Download citation

  • Issue Date:

  • DOI:


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing