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Prevention of a Genetically Determined Congenital Eye Anomaly in the Mouse by the Administration of Cortisone During Pregnancy


THE mouse is normally born with its eyelids fused. This fusion occurs on approximately the 17th day of gestation (full-term 19–20 days), and the eyelids do not open again until approximately 14 days after birth1. If fusion does not occur, the eye of the new-born animal is exposed to injury and infection which result in abnormalities of structure and function in adult life. Thus, ‘eyelids open at birth’ constitutes a congenital defect in the mouse.

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WATNEY, M., MILLER, J. Prevention of a Genetically Determined Congenital Eye Anomaly in the Mouse by the Administration of Cortisone During Pregnancy. Nature 202, 1029–1031 (1964).

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