Abstract
THE mouse is normally born with its eyelids fused. This fusion occurs on approximately the 17th day of gestation (full-term 19–20 days), and the eyelids do not open again until approximately 14 days after birth1. If fusion does not occur, the eye of the new-born animal is exposed to injury and infection which result in abnormalities of structure and function in adult life. Thus, ‘eyelids open at birth’ constitutes a congenital defect in the mouse.
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WATNEY, M., MILLER, J. Prevention of a Genetically Determined Congenital Eye Anomaly in the Mouse by the Administration of Cortisone During Pregnancy. Nature 202, 1029–1031 (1964). https://doi.org/10.1038/2021029a0
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DOI: https://doi.org/10.1038/2021029a0
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