IN view of the high percentage of relapses in cases of brucellosis treated with the antibiotics now in use, we have examined the in vitro effect of synnematin B on Brucella. This antibiotic is unique among the penicillins in that it possesses remarkable activity against a narrow spectrum of Gram-negative organisms. Synnematin B has proved capable of controlling experimental infections in mice caused by Salmonella and Proteus1–3 and natural infections in man4–6. Cultures of mouse fibroblast cells infected with Salmonella typhosa have been freed regularly of infection by treatment with synnematin7. Bacteriostasis of Brucella by 1–2 units/ml. of the antibiotic and bactericidal action against Brucella abortus with 100 units/ml. have been reported8,9. No other reports are known.
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RICHARDSON, M., HOLT, J. Effect of Synnematin B on Brucella. Nature 202, 1010–1012 (1964). https://doi.org/10.1038/2021010b0
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