Role of Interferon in Viral Interference

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ACTINOMYCIN D inhibits the production of interferon1. Since the exact role of interferon in the phenomenon of viral interference has not been fully established, the effect of actinomycin D on viral interference was tested. The present results show that when actinomycin D inhibited interferon production by a heat-inactivated arbovirus, it also reversed viral interference by the virus.

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FRIEDMAN, R. Role of Interferon in Viral Interference. Nature 201, 848–849 (1964) doi:10.1038/201848a0

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