Abstract
SINCE the pioneer work of Murphy1 the embryonated hen's egg has been widely used for the propagation of tumours of heterologous origin. Although murine lymphomas generally do not propagate well when transplanted in this manner, some of them not known to be associated with a virus are capable of limited growth. Karnofsky et al.2 showed that lymphosarcoma P3269 was capable of slight growth and survival for two passages on the chorioallantoic membrane, while six other leukæmias gave negative results. Clarkson and Katz3 found that P388 leukæmia would not grow on the chorioallantoic membrane, but they did observe multiple small cellular deposits in various organs, notably the brain. These persisted for up to one month after hatching.
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References
Murphy, J. B., J. Amer. Med. Assoc., 59, 874 (1912).
Karnofsky, D. A., Ridgway, L. P., and Patterson, P. A., Ann. N.Y. Acad. Sci., 55, 313 (1952).
Clarkson, B. D., and Katz, A., Proc. Amer. Assoc. Cancer Res., 3, 101 (1960).
Dawson, P. J., Fieldsteel, A. H., and Bostick, W. L., Cancer Res., 23, 349 (1963).
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DAWSON, P., FIELDSTEEL, A., BOSTICK, W. et al. Growth of a Reticulum Cell Sarcoma Variant of Friend Disease in the Embryonated Hen's Egg. Nature 201, 91–92 (1964). https://doi.org/10.1038/201091a0
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DOI: https://doi.org/10.1038/201091a0
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