Amphotericin B in the Chemotherapy of Experimental Schistosomiasis mansoni in Swiss Mice

Abstract

IN May 1963, Gordon, St. John and Olsen1 reported the prolongation of life in Swiss mice experimentally infected with a Puerto Rican strain of Schistosoma mansoni, when treated for 5 days with ‘Fungizone’ (amphotericin B made soluble with deoxycholate ; E. R. Squibb). In the foregoing experiment, treatment began at a level of 0.5 mg of ‘Fungizone’/kg body-weight of mouse a day. The dosage was increased in two daily increments of 0.5 mg/kg to a final level of 1.5 mg/kg a day, which was maintained for three days. Treatment began twelve weeks after infection (approximately 6 weeks after the parasite had begun producing ova). By one week subsequent to the termination of treatment, 80 per cent of the untreated but only 27 per cent of the treated animals had died. A χ2 test showed that the experimental results fit to a confidence limit of 98 per cent the hypothesis that treatment influenced survival.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Gordon, B. L., St. John, P. A., and Olsen, G., Bact. Proc., 95 (1963).

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

GORDON, B., JOHN, P. Amphotericin B in the Chemotherapy of Experimental Schistosomiasis mansoni in Swiss Mice. Nature 200, 790–791 (1963). https://doi.org/10.1038/200790b0

Download citation

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing