Abstract
SINCE the localization of tetracyclines in newly formed bone was first reported1 these drugs have been used in investigations of bone activity2,3 and bone growth4. In the course of an examination of bone activity in the mandible of the cat it was noticed that although successive injections of tetracycline were given at equal time-intervals successive labels were not evenly spaced. As the osteon formed, the rate of formation appeared to diminish. This ‘maturation effect’ has been noticed by other authors5. It was thought that some assessment of this rate of diminution might be interesting, particularly if this information could be used to shed light on factors influencing deposition of bone.
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References
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MANSON, J., WATERS, N. Maturation Rate of the Osteon of the Cat. Nature 200, 489–490 (1963). https://doi.org/10.1038/200489b0
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DOI: https://doi.org/10.1038/200489b0
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