Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Induction by 5-Fluorouracil of Bacteriophage Development in Lysogenic E. coil K12 (λ)

Nature volume 200, pages 487–488 (1963)Cite this article

Abstract

EXPOSURE to ionizing or ultra-violet radiation or radio-mimetic chemicals has long been known to induce the vegetative reproduction of certain temperate bacterio-phages in lysogenic bacteria1. Cytotoxic agents, such as mitomycin C (ref. 2), and folic acid antagonists, such as aminopterin3, have also been reported to be inducing agents. Recently, phage induction has been observed after thymine deprivation in lysogenic thymine-deficient mutant strains4,5.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Cf. Lwoff, A., Bact. Rev., 17, 269 (1953).

    CAS  PubMed  Google Scholar 

  2. Otsuji, N., Sekiguchi, M., Iijima, T., and Takagi, Y., Nature, 184, 1079 (1959).

    Article  ADS  CAS  Google Scholar 

  3. Ben-Gurion, R., Biochem. Biophys. Res. Comm., 8, 456 (1962).

    Article  CAS  Google Scholar 

  4. Melechen, N. E., and Skaar, P. D., Virology, 16, 21 (1962).

    Article  CAS  Google Scholar 

  5. Korn, D., and Weissbach, A., Biochim. Biophys. Acta, 61, 775 (1962).

    CAS  PubMed  Google Scholar 

  6. Heidelberger, C., et al., Nature, 179, 663 (1957).

    Article  ADS  CAS  Google Scholar 

  7. Cohen, S. S., et al., Proc. U.S. Nat. Acad. Sci., 44, 1004 (1958).

    Article  ADS  CAS  Google Scholar 

  8. Horowitz, J., and Chargaff, E., Nature, 184, 1213 (1959).

    Article  ADS  CAS  Google Scholar 

  9. Kaplan, H. S., Smith, K. C., and Tomlin, P. A., Rad. Res., 16, 98 (1962).

    Article  CAS  Google Scholar 

  10. Goodman, F., Saukkonen, J. J., and Chargaff, E., Biochim. Biophys. Acta 44, 458 (1960).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Service de Radiobiologie et de Cancerologie, Institut Pasteur, Paris, France

    HERBERT MARCOVICH

  2. Department of Radiology, Stanford University School of Medicine, Palo Alto, California

    HENRY S. KAPLAN

Authors
  1. HERBERT MARCOVICH
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. HENRY S. KAPLAN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

MARCOVICH, H., KAPLAN, H. Induction by 5-Fluorouracil of Bacteriophage Development in Lysogenic E. coil K12 (λ). Nature 200, 487–488 (1963). https://doi.org/10.1038/200487a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/200487a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing