Nature 391, 177–181 (1998)
In this Letter, we reported that invariant Vα24JαQ T cells from monozygotic diabetic twins/triplets were reduced in number and produced only interferon-γ on appropriate stimulation, whereas those cloned from at-risk non-diabetic twins/triplets and controls produced both interferon-γ and interleukin(IL)-4. We also reported (see our Fig. 4 ) that 50% (7/14) of high-risk diabetes non-progressors had markedly raised levels of serum IL-4, as measured by ELISA. However, we now find that measurement of serum IL-4 by ELISA is confounded by the presence in some serum samples of a heterophile-like substance(s) that gives false positive estimations for IL-4 by crosslinking the capture and detection antibodies used in the assay1,2. This is not the case when IL-4 is measured in the tissue-culture medium of in vitro activated T cells. Details will be published once the source of error is determined, a method for accurate measurement of serum IL-4 is established, and the apparent association of production of the heterophile substance and/or IL-4 with diabetic non-progression has been clarified.
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The online version of the original article can be found at 10.1038/34419
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Wilson, S., Kent, S., Patton, K. et al. Erratum: Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes. Nature 399, 84 (1999). https://doi.org/10.1038/20007
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DOI: https://doi.org/10.1038/20007
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