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Potentiation of the Anti-reserpine Effects of Dihydroxyphenylalanine by Antidepressants and Stimulants

Naturevolume 199pages917918 (1963) | Download Citation

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Abstract

DIHYDROXYPHENYLALANINE (DOPA), the biological precursor of the catecholamines1, causes stimulation of the central nervous system in normal mice2 and mice treated with reserpine3. In the latter the effects of DOPA are dramatic; the mice are aroused from the reserpine-induced depression and become normal or hyperactive in behaviour3. Such arousal is thought to be effected through repletion of the reserpine-depleted catecholamines3

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References

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Affiliations

  1. Department of Pharmacology, Wm. S. Merrell Co., Division of Richardson-Merrell Inc., Cincinnati, Ohio

    • W. R. MCGRATH
    •  & H. J. KETTELER

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https://doi.org/10.1038/199917a0

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