Letter | Published:

Antitussive Activity of a New Local Anæsthetic Compound : Benzobutamine

Naturevolume 199pages916917 (1963) | Download Citation

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Abstract

INVESTIGATIONS of the relationships between the anti-tussive activity and other pharmacological properties of many known drugs1 led us to conclude that local anæsthetic effect was very important in order to predict the antitussive activity of new compounds, especially if this action is accompanied by other pharmacological effects such as the antispasmodic and antihistaminic ones. A systematic investigation was then carried out on new synthetic derivatives possessing local anæsthetic properties in different degrees. The compound N (2-benzoyloxy-methyl-2-phenylbutyl)-N,N dimethylamine (benzobut-amine)2 was found to have the most interesting anti-tussive activity among a series of many other related compounds. Benzobutamine displays local anæsthetic properties and, at the same time, shows antispasmodic, anticonvulsant and antihistaminic effects. In this communication a description of the pharmacological properties of this drug is given.

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References

  1. 1

    Silvestrini, B., and Maffii, G., Farmaco (Ed. Sci.), 14, 440 (1959).

  2. 2

    Vecchi, A., Melone, G., and Maffii, G., Farmaco (Ed. Sci.), 14, 697 (1959).

  3. 3

    Randall, L. O., and Selitto, J. J., Arch. Int. Pharmacodyn., 111, 409 (1957).

  4. 4

    Winter, C. A., and Flataker, L., Proc. Soc. Exp. Biol. Med., 81, 463 (1952).

  5. 5

    Stefko, P. L., and Benson, W. M., J. Pharm. Exp. Therap., 108, 217 (1953).

  6. 6

    Domenjoz, R., Arch. Exp. Path. Pharmakol., 215, 19 (1952).

  7. 7

    Eddy, N. B., and Sumwalt, M., J. Pharm. Exp. Therap., 67, 127 (1939).

  8. 8

    Pellmont, B., and Bächtold, M., Schweiz. Med. Wschr., 84, 1368 (1954).

  9. 9

    Bein, H. J., and Bucher, K., Helv. Physiol. Acta, 15, 55 (1957).

  10. 10

    Aurousseau, M., and Navarro, J., Ann. Pharm. Franc., 15, 640 (1957).

  11. 11

    Pasquariello, G., and Nicolis, F. B., Clinica Terap., 23, 226 (1962).

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Author notes

    • B. SILVESTRINI

    Present address: Department of Pharmacology, Research Laboratories, A.C.R. Angelini Francesco, Rome

Affiliations

  1. Department of Pharmacology, Lepetit S.p.A. Research Laboratories, Milan

    • G. MAFFII
    • , B. SILVESTRINI
    •  & S. BANFI

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https://doi.org/10.1038/199916a0

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