Letter | Published:

A New Metabolic Regulator : its Stimulation of Citric Acid Production and Anti-sulphon-amide and Streptomycin Effect

Naturevolume 199pages905906 (1963) | Download Citation

Subjects

Abstract

ALTHOUGH at present many data are available concerning the production of citric acid by fungi1–5, very little is known of the mechanism by which the production of this acid is regulated. Its production in Aspergillus niger varies greatly with the strain and the medium6,7. The same strain, under various conditions, is capable in one case of converting practically all the sugar available into citric acid; in another case production is decreased by the conditions of the reaction practically to zero.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Shu, P., and Johnson, M. J., Indust. Eng. Chem., 40, 1202 (1948).

  2. 2

    Martin, S. M., Wilson, P. W., and Burris, R. H., Arch. Biochem., 26, 103 (1950).

  3. 3

    Foster, J. W., and Carson, S. F., J. Amer. Chem. Soc., 72, 1865 (1950).

  4. 4

    Lewis, K. F., and Weinhouse, W. G., J. Amer. Chem. Soc., 73, 2906 (1951).

  5. 5

    Kornberg, H. L., and Krebs, H. A., Nature, 179, 988 (1957).

  6. 6

    Leopold, H., and Fencl, Z., Chem. Technik, 10, 507 (1958).

  7. 7

    Zhuravskii, G. I., et al., Proizvodstvo pishchevykh kislot. (Pishchepromizdat, Moscow, 1953).

  8. 8

    Fencl, Z., and Vintrova, E., Czechoslovak Patent Application PV 2698-61.

  9. 9

    Nossal, P. M., Austral. J. Exp. Biol. Med. Sci., 31, 583 (1953).

  10. 10

    Rajagopalan, K. V., Radhakrishnamurthy, R., and Sarma, P. S., Nature, 184, 461 (1959).

  11. 11

    Novelli, G. D., and Lipmann, F., J. Biol. Chem., 182, 213 (1950).

  12. 12

    Stern, R. J., and Ochoa, S., J. Biol. Chem., 179, 491 (1949).

  13. 13

    Vrba, R., and Burger, M., Chem. listy, 46, 175 (1952).

Download references

Author information

Affiliations

  1. Institute of Microbiology, Czechoslovak Academy of Sciences, Prague, 6

    • Z. FENCL
    •  & E. VINTROVÁ

Authors

  1. Search for Z. FENCL in:

  2. Search for E. VINTROVÁ in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/199905a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.