Letter | Published:

Antigenic Activity of Tryptic Peptides of Tobacco Mosaic Virus Protein

Naturevolume 199pages831832 (1963) | Download Citation

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Abstract

FRAGMENTS possessing immunological activity related to that of the whole protein have been obtained from several protein antigens. Enzymatic digests of silk fibroin1, γ-globulin2,3, and serum albumin4,5 have exhibited such activity. A recent report from our laboratory showed that fragments of egg albumin obtained by partial acid hydrolysis of the protein inhibited both the in vitro interaction of the protein with homologous anti-serum and systemic anaphylaxis in guinea pigs6. Although active fragments have been obtained, analysis of their composition and structure is extremely difficult.

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Affiliations

  1. Laboratory of Medical Entomology, Kaiser Foundation Research Institute, San Francisco

    • JANIS D. YOUNG
    • , E. BENJAMINI
    • , M. SHIMIZU
    • , CHERRY Y. LEUNG
    •  & BEN F. FEINGOLD

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https://doi.org/10.1038/199831b0

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