Abstract
FRAGMENTS possessing immunological activity related to that of the whole protein have been obtained from several protein antigens. Enzymatic digests of silk fibroin1, γ-globulin2,3, and serum albumin4,5 have exhibited such activity. A recent report from our laboratory showed that fragments of egg albumin obtained by partial acid hydrolysis of the protein inhibited both the in vitro interaction of the protein with homologous anti-serum and systemic anaphylaxis in guinea pigs6. Although active fragments have been obtained, analysis of their composition and structure is extremely difficult.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Cebra, J. J., J. Immunol., 86, 205 (1961).
Porter, R. R., Biochem. J., 73, 119 (1959).
Goodman, J. W., Science, 139, 1292 (1963).
LaPresle, C., and Durieuz, J., Ann. Inst. Pasteur, 92, 62 (1957).
Press, E. M., and Porter, R. R., Biochem. J., 83, 172 (1962).
Benjamini, E., Feingold, Ben F., Young, J. D., and Shimizu, M., Fed. Proc., 21, 11 (1962).
Brown, R. K., J. Biol. Chem., 237, 1162 (1962).
Tsugita, A., Gish, D. T., Young, J., Fraenkel-Conrat, H., Knight, C. A., and Stanley, W. M., Proc. U.S. Nat. Acad. Sci., 46, 1463 (1960).
Anderer, F. A., Naturforschg., 17, b, 536 (1962).
Fraenkel-Conrat, H., Virology, 4, 1 (1957).
Wittman, H. G., Braunitzer, G., Virology, 9, 726 (1959).
Funatsu, G. (personal communication).
Woody, B. R., and Knight, C. A., Virology, 9, 359 (1959).
Ovary, Z., Immunology, 3, 19 (1960).
Kabat, E. A., and Mayer, M. M., Experimental Immunochemistry, 311 (C. Thomas, Springfield, Ill., second ed., 1961).
Anderer, F. A., Biochim. Biophys. Acta, 71, 246 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
YOUNG, J., BENJAMINI, E., SHIMIZU, M. et al. Antigenic Activity of Tryptic Peptides of Tobacco Mosaic Virus Protein. Nature 199, 831–832 (1963). https://doi.org/10.1038/199831b0
Issue Date:
DOI: https://doi.org/10.1038/199831b0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.