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Effect of Multiple Injections of Calcium Compounds on the Survival of X-irradiated Rats

Naturevolume 199pages821822 (1963) | Download Citation

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Abstract

A MODERATE increase in the survival of X-irradiated rats has been observed when either parathyroid extract or ethylenediamine tetraacetate (EDTA) was injected before or after mid-lethal doses of X-rays1–3. The action of these substances has been attributed to bone resorption, which was thought to protect the adjacent radiosensitive bone marrow by exposing it to an increased concentration of newly-released calcium. In the work recorded here, we have tested this view directly by the injection of calcium compounds.

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References

  1. 1

    Rixon, R. H., Whitfield, J. F., and Youdale, T., Nature, 182, 1374 (1958).

  2. 2

    Rixon, R. H., and Whitfield, J. F., Intern. J. Rad. Biol., 3, 361 (1961).

  3. 3

    Rixon, R. H., and Whitfield, J. F., Intern. J. Rad. Biol., 3, 439 (1961).

  4. 4

    Rixon, R. H., and Stevenson, J. A. F., Amer. J. Physiol., 194, 363 (1958).

  5. 5

    Barnes, J. H., and Philpot, J. St. L., Nature, 192, 574 (1961).

  6. 6

    Gosselin, R. E., Tidball, C. S., Megiran, R., Maynard, E. A., Downs, W. L., and Hodge, H. C., J. Pharmacol. Exp. Therap., 108, 117 (1953).

  7. 7

    Gosselin, R. E., and Coghlan, E. R., Arch. Biochem. Biophys., 45, 301 (1953).

  8. 8

    Blount, H. C., Radiology, 65, 250 (1955).

  9. 9

    Mikhailov, V., and Bozduganov, A., Meditsinskaya Radiologiya, 6, 75 (1961).

  10. 10

    O'Dell, B. L., Fed. Proc., 19, 648 (1960).

  11. 11

    Myers, D. K., and DeWolfe, D. E., Intern. J. Radiol. Biol., 5, 195 (1962).

  12. 12

    Hagen, U., Strahlentherapie, 117, 119 (1962).

  13. 13

    Whitfield, J. F., and Rixon, R. H., Exp. Cell Res., 27, 154 (1962).

  14. 14

    Bronner, F., in The Parathyroids, edit. by Greep, R. O., and Talmage, R. V., 123 (C. C. Thomas, 1961).

  15. 15

    Petrova, N. D., Polikarpova, L. T., Sbitneva, M. F., Tutochkina, L. T., and Shikhodyrov, V. V., Meditsinskaya Radiologiya, 3, 34 (1958).

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Author notes

    • J. F. WHITFIELD

    Present address: Biologie, Euratom (C.C.R.), Ispra, Italy

Affiliations

  1. Biology Branch, Division of Biology and Health Physics, Atomic Energy of Canada, Ltd., Chalk River, Ontario

    • R. H. RIXON
    •  & J. F. WHITFIELD

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https://doi.org/10.1038/199821b0

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