Letter | Published:

Action of 5-Bromo-3-sec-Butyl-6-Methyluracil as Regards Replacement of Thymine in Mouse DNA

Naturevolume 199pages810811 (1963) | Download Citation



McGahen and Hoffmann1 were unable to demonstrate thymine replacement by 5-bromo-3-sec-butyl-methyluracil (I) in a thymineless Escherichia coli while 5-bromouracil (II) replaced 21 per cent of the thymine under the same test conditions. It was concluded that 5-bromo-3-sec-butyl-6-methyluracil is not, therefore, a biological analogue of thymine. The results of an investigation with juvenile mice are presented here.

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  1. 1

    McGahen, J. W., and Hoffmann, C. E. (in the press).

  2. 2

    Marmur, J., J. Mol. Biol., 3, 208 (1961).

  3. 3

    Burton, K. Biochem. J., 62, 315 (1956).

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  1. Stine Laboratory, Industrial and Biochemicals Department, E. I. du Pont de Nemours and Co., Newark, Delaware

    • J. W. MCGAHEN
    •  & C. E. HOFFMANN


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