Abstract
McGahen and Hoffmann1 were unable to demonstrate thymine replacement by 5-bromo-3-sec-butyl-methyluracil (I) in a thymineless Escherichia coli while 5-bromouracil (II) replaced 21 per cent of the thymine under the same test conditions. It was concluded that 5-bromo-3-sec-butyl-6-methyluracil is not, therefore, a biological analogue of thymine. The results of an investigation with juvenile mice are presented here.
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References
McGahen, J. W., and Hoffmann, C. E. (in the press).
Marmur, J., J. Mol. Biol., 3, 208 (1961).
Burton, K. Biochem. J., 62, 315 (1956).
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MCGAHEN, J., HOFFMANN, C. Action of 5-Bromo-3-sec-Butyl-6-Methyluracil as Regards Replacement of Thymine in Mouse DNA. Nature 199, 810–811 (1963). https://doi.org/10.1038/199810a0
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DOI: https://doi.org/10.1038/199810a0
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