Letter | Published:

Effects of Puromycin on Morphogenesis in Amphibian Eggs and Acetabularia mediterranea

Naturevolume 199pages714715 (1963) | Download Citation



THE effects of actinomycin D, an antibiotic which is a specific inhibitor of the enzyme DNA primed-RNA polymerase, on morphogenesis in amphibian eggs and in the alga Acetabularia mediterranea have been presented in a preceding communication1. It was shown that inhibition of nuclear RNA synthesis (presumably messenger-RNA synthesis) results in the inhibition of cephalo-caudal and dor so-ventral differentiation, in amphibian embryos.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Brachet, J., and Denis, H., Nature, 198, 205 (1963).

  2. 2

    Allen, D. W., and Zamecnik, P. C., Biochim. Biophys. Acta, 55, 865 (1962).

  3. 3

    Werz, G., Planta, 55, 22 (1960).

  4. 4

    Olszewska, M. J., de Vitry, F., and Brachet, J., Exp. Cell Res., 24, 58 (1961).

Download references

Author information


  1. Laboratoire de Morphologie animale, Faculté des Sciences de l'Université libre, Bruxelles

    • J. BRACHET


  1. Search for J. BRACHET in:

About this article

Publication history

Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.