Letter | Published:

Effects of Puromycin on Morphogenesis in Amphibian Eggs and Acetabularia mediterranea

Naturevolume 199pages714715 (1963) | Download Citation

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Abstract

THE effects of actinomycin D, an antibiotic which is a specific inhibitor of the enzyme DNA primed-RNA polymerase, on morphogenesis in amphibian eggs and in the alga Acetabularia mediterranea have been presented in a preceding communication1. It was shown that inhibition of nuclear RNA synthesis (presumably messenger-RNA synthesis) results in the inhibition of cephalo-caudal and dor so-ventral differentiation, in amphibian embryos.

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References

  1. 1

    Brachet, J., and Denis, H., Nature, 198, 205 (1963).

  2. 2

    Allen, D. W., and Zamecnik, P. C., Biochim. Biophys. Acta, 55, 865 (1962).

  3. 3

    Werz, G., Planta, 55, 22 (1960).

  4. 4

    Olszewska, M. J., de Vitry, F., and Brachet, J., Exp. Cell Res., 24, 58 (1961).

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  1. Laboratoire de Morphologie animale, Faculté des Sciences de l'Université libre, Bruxelles

    • J. BRACHET

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https://doi.org/10.1038/199714a0

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