Letter | Published:

An Attempt to demonstrate in vivo Recognition of Ectopically Placed Autologous Tissues

Naturevolume 199pages712713 (1963) | Download Citation



THE organization and control of growth of the normal tissues of the body has been related by Green1 to the presence on the surface of normal cells of specific reactive sites, which are thought to be lipoproteins2. These he called tissue specific antigens, and these antigens were postulated to undergo a modification when cells become displaced outside their normal environment3, and thereby alert the disposal mechanisms of the body which prevent the growth of ectopically placed autologous tissues. An attempt has therefore been made to design a system to demonstrate an immune response to ectopically placed autologous tissues.

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  1. 1

    Green, H. N., Brit. Med. J., ii, 1378 (1954).

  2. 2

    Vogt, P., Nature, 182, 1807 (1958).

  3. 3

    Anderson, M. R., and Green, H. N., Nature, 198, 859 (1963).

  4. 4

    Branster, M. V., and Morton, R. K., Nature, 180, 1283 (1957).

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  1. Department of Experimental Pathology and Cancer Research, School of Medicine, University of Leeds



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