Letter | Published:

Immunization against Cryptococcus neoformans by Capsular Polysaccharide

Naturevolume 199page710 (1963) | Download Citation



IT has been reported1 that crude Cryptococcus neoformans capsular polysaccharide when injected by the subcutaneous route was incapable of protecting mice against a lethal challenge dose of the parent organism. Purified polysaccharide, on the other hand, elicited a minimal protective response which was markedly increased by coupling to an ion exchange resin adjuvant. Both polysaccharides were obtained by direct recovery from cell-free culture medium. More recently it was shown indirectly that the protective antigen appeared to be concentrated in an area of the capsule immediately surrounding the cell wall2. It was therefore of interest to determine if fractionation of the capsule by repeated grinding would provide antigens with increased stimulatory properties.

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  1. 1

    Gadebusch, H. H., J. Infect. Dis., 102, 219 (1958).

  2. 2

    Gadebusch, H. H., J. Infect. Dis., 107, 406 (1960).

  3. 3

    Landy, M., and Trapani, R. J., Amer. J. Hyg., 59, 150 (1954).

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  1. General Medical Research Section, U.S. Veterans Administration Hospital, Ann Arbor, Michigan



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