Letter | Published:

Ribosomes Active in Protein Synthesis in Human Reticulocytes : a Defect in Thalassæmia Major

Naturevolume 199pages706707 (1963) | Download Citation



THE most prominent abnormality in thalassæmia major appears to be a decreased synthesis of hæmoglobin A1,2. Ingram and Stretton3 have suggested that this defect in synthesis may be associated with an alteration in the amino-acid sequence of the hæmoglobin which does not alter the electrophoretic mobility of the tryptic pep tides. However, no abnormalities have yet been detected in any of the types of hæmoglobin found in thalassæmia4. An alternative hypothesis1–3 proposes that the defect involves only an altered rate of synthesis of hæmoglobin A.

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  1. 1

    Rich, A., Proc. U.S. Nat. Acad. Sci., 38, 187 (1952).

  2. 2

    Itano, H., Adv. Protein Chem., 12, 215 (1957).

  3. 3

    Ingram, V. M., and Stretton, A. O. W., Nature, 184, 1903 (1959).

  4. 4

    Baglioni, C., Molecular Genetics, edit. by Taylor, J. H., 1, 405 (Academic Press, New York, 1963).

  5. 5

    Marks, P. A., Burka, E. R., and Schlessinger, D., Proc. U.S. Nat. Acad. Sci., 48, 2163 (1962).

  6. 6

    Warner, J. R., Knopf, P. M., and Rich, A., Proc. U.S. Nat. Acad. Sci., 49, 122 (1963).

  7. 7

    Marks, P. A., Rifkind, R., and Danon, D., Proc. U.S. Nat. Acad. Sci. (in the press).

  8. 8

    Britten, R. J., and Roberts, R. B., Science, 131, 33 (1960).

  9. 9

    Burka, E. R., and Marks, P. A., J. Clin. Invest., 42. 921 (1963).

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  1. Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, 32

    •  & PAUL A. MARKS


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