Abstract
THE most prominent abnormality in thalassæmia major appears to be a decreased synthesis of hæmoglobin A1,2. Ingram and Stretton3 have suggested that this defect in synthesis may be associated with an alteration in the amino-acid sequence of the hæmoglobin which does not alter the electrophoretic mobility of the tryptic pep tides. However, no abnormalities have yet been detected in any of the types of hæmoglobin found in thalassæmia4. An alternative hypothesis1–3 proposes that the defect involves only an altered rate of synthesis of hæmoglobin A.
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References
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BURKA, E., MARKS, P. Ribosomes Active in Protein Synthesis in Human Reticulocytes : a Defect in Thalassæmia Major. Nature 199, 706–707 (1963). https://doi.org/10.1038/199706a0
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DOI: https://doi.org/10.1038/199706a0
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