Letter | Published:

Medullary Vagal Effects of d-Lysergic Acid Diethylamide in the Decerebrate Cat

Naturevolume 199pages700701 (1963) | Download Citation



DESPITE the fact that 2-brom-d-lysergic acid (BOL-148) and d-lysergic acid diethylamide (LSD-25) are both potent anti-metabolites of serotonin in vitro1,2, they do not exhibit similar behavioural or pharmacological effects in vivo. LSD-25 has been shown to produce bradycardia, a decrease in respiratory rate and hypotension in the pento-barbitalized, intact cat3. This is in contrast to the hypertension and tachycardia produced in spinal animals. The explanation advanced for these effects has been that in the intact animal the hypertension and tachycardia, due to peripheral vasoconstriction, are masked by more potent effects of LSD-25 on higher centres. BOL-148 was also shown to have no effect on heart rate and a weak nonspecific effect on blood pressure in the intact anæsthetized cat in doses up to 1 mg/kg (ref. 3). In the decerebrate cat, ergot alkaloids cause hypotension and bradycardia via medullary vagal centres4,5. Therefore, we attempted to study possible vagal effects of LSD-25 and BOL-148 in the decerebrate cat.

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    Present address: Department of Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, 3, New York


  1. Experimental Medicine and Neuropharmacology Branch, U.S. Army Chemical Warfare Laboratories, Army Chemical Center, Maryland



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