Letter | Published:

Effect of Orotic Acid on the Synthesis of Citrovorum Factor and of Methionine in Liver of the Chick

Naturevolume 199pages695696 (1963) | Download Citation



IN a dietary condition in which only B12 of the vitamins and methionine of the amino-acids are active for growth in the chick, it has been demonstrated that orotic acid is a growth factor1. One biochemical hypothesis on the effect of orotic acid in B12 and methionine deficiency is that orotic acid acts in the metabolism of the 1–C unit.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Moruzzi, G., Viviani, R., and Marchetti, M., Biochem. Z., 333, 318 (1960).

  2. 2

    Spivey Fox, M. R., Briggs, G. M., and Ortiz, L. O., J. Nutrition, 62, 639 (1957).

  3. 3

    Moruzzi, G., Marchetti, M., and Viviani, R., Arch. ital. Biol. (submitted for publication).

  4. 4

    Wagle, S. R., Mehta, R., and Connor Johnson, B., J. Biol. Chem., 233, 619 (1958).

  5. 5

    Huennekens, F. M., and Osborn, M. J., in Adv. Enzymol., 21, 369 (1959).

  6. 6

    Foster, M. A., Johnes, K. M., and Woods, D. D., Biochem. J., 80, 519 (1961).

  7. 7

    Arnstein, H. R. V., and Neuberger, A., Biochem. J., 55, 259 (1953).

  8. 8

    Hoagland, M. B., in Proc. Fourth Intern. Cong. Biochem., Vienna, 8, 199 (1958).

  9. 9

    Hiibscher, G., Dils, R. R., and Pover, W. F. R., Biochim. Biophys. Acta, 36, 518 (1959).

Download references

Author information


  1. Istituto di Chimica biologica dell' Universitá di Bologna



  1. Search for GIOVANNI MORUZZI in:

  2. Search for MARIO MARCHETTI in:

  3. Search for ROMANO VIVIANI in:

About this article

Publication history

Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.