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Differential Behaviour of Transplanted Mouse Lymphoma Lines in Genetically Compatible Homozygous and F1 Hybrid Mice

Nature volume 199, pages 614–615 (1963)Cite this article

Abstract

TUMOURS induced in F1 hybrids between two isogenic resistant mouse strains, differing at the histocompatibility-2 locus, occasionally give variant lines, compatible with one or the other of the parental strains, entering the F1 cross1,2. Such variants have irreversibly lost the histocompatibility-2 antigens, determined by one of the parents. The mechanism of variant formation has been tentatively attributed to somatic crossing-over, even if deletion of a terminal chromosome segment cannot be excluded1–4.

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Authors and Affiliations

  1. Institute for Tumour Biology, Karolinska Institutet Medical School, Stockholm

    K. E. HELLSTRÖM

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  1. K. E. HELLSTRÖM
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HELLSTRÖM, K. Differential Behaviour of Transplanted Mouse Lymphoma Lines in Genetically Compatible Homozygous and F1 Hybrid Mice. Nature 199, 614–615 (1963). https://doi.org/10.1038/199614a0

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  • DOI: https://doi.org/10.1038/199614a0

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