Letter | Published:

Differential Behaviour of Transplanted Mouse Lymphoma Lines in Genetically Compatible Homozygous and F1 Hybrid Mice

Naturevolume 199pages614615 (1963) | Download Citation

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Abstract

TUMOURS induced in F1 hybrids between two isogenic resistant mouse strains, differing at the histocompatibility-2 locus, occasionally give variant lines, compatible with one or the other of the parental strains, entering the F1 cross1,2. Such variants have irreversibly lost the histocompatibility-2 antigens, determined by one of the parents. The mechanism of variant formation has been tentatively attributed to somatic crossing-over, even if deletion of a terminal chromosome segment cannot be excluded1–4.

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References

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Affiliations

  1. Institute for Tumour Biology, Karolinska Institutet Medical School, Stockholm

    • K. E. HELLSTRÖM

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https://doi.org/10.1038/199614a0

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