Letter | Published:

Differential Behaviour of Transplanted Mouse Lymphoma Lines in Genetically Compatible Homozygous and F1 Hybrid Mice

Naturevolume 199pages614615 (1963) | Download Citation



TUMOURS induced in F1 hybrids between two isogenic resistant mouse strains, differing at the histocompatibility-2 locus, occasionally give variant lines, compatible with one or the other of the parental strains, entering the F1 cross1,2. Such variants have irreversibly lost the histocompatibility-2 antigens, determined by one of the parents. The mechanism of variant formation has been tentatively attributed to somatic crossing-over, even if deletion of a terminal chromosome segment cannot be excluded1–4.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Klein, E., Klein, G., and Hellström, K. E., J. Nat. Cancer Inst., 25, 271 (1960).

  2. 2

    Hellström, K. E., J. Nat. Cancer Inst., 25, 237 (1960).

  3. 3

    Klein, E., J. Nat. Cancer Inst., 27, 1069 (1961).

  4. 4

    Hellström, K. E., J. Nat. Cancer Inst., 27, 1095 (1961).

  5. 5

    Schrek, R., Amer. J. Cancer, 28, 389 (1936).

  6. 6

    Linder, O., and Klein, E., J. Nat. Cancer Inst., 24, 707 (1960).

  7. 7

    Snell, G. D., J. Nat. Cancer Inst., 21, 843 (1958).

  8. 8

    Snell, G. D., and Stevens, L. C., Immunology, 4, 366 (1961).

  9. 9

    Barski, G., Sorieul, S., and Cornefert, F., C.R. Acad. Sci., Paris, 251, 1825 (1960).

Download references

Author information


  1. Institute for Tumour Biology, Karolinska Institutet Medical School, Stockholm



  1. Search for K. E. HELLSTRÖM in:

About this article

Publication history

Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.