Letter | Published:

Carcinogenic Action of N-hydroxy-4-acetylaminostilbene

Naturevolume 199pages613614 (1963) | Download Citation

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Abstract

RECENT investigations1,2 have indicated that 2-acetyl-aminofluorene and 4-acetylaminobiphenyl are metabolized to N-hydroxy derivatives in the rat and these metabolites are more carcinogenic than the parent amides. Thus, N-hydroxy-4-acetylaminobiphenyl was as active as the parent amide as a mammary carcinogen and in addition induced a higher incidence of ear-duct carcinomata and forestomach papillomata2.

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References

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    Miller, J. A., Cramer, J. W., and Miller, E. C., Cancer Res., 20, 950 (1960).

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    Andersen, R. A., Enomoto, M., Miller, J. A., and Miller, E. C., Proc. Amer. Assoc. Cancer Res., 4, 2 (1963).

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    Somers, C. E., and Hsu, T. C., Proc. U.S. Nat. Acad. Sci., 48, 937 (1962).

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Author information

Affiliations

  1. Cancer Research Laboratory, University of Nottingham

    • R. W. BALDWIN
    • , W. R. D. SMITH
    •  & S. J. SURTEES

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DOI

https://doi.org/10.1038/199613a0

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