Letter | Published:

Carcinogenic Action of N-hydroxy-4-acetylaminostilbene

Naturevolume 199pages613614 (1963) | Download Citation



RECENT investigations1,2 have indicated that 2-acetyl-aminofluorene and 4-acetylaminobiphenyl are metabolized to N-hydroxy derivatives in the rat and these metabolites are more carcinogenic than the parent amides. Thus, N-hydroxy-4-acetylaminobiphenyl was as active as the parent amide as a mammary carcinogen and in addition induced a higher incidence of ear-duct carcinomata and forestomach papillomata2.

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    Miller, J. A., Cramer, J. W., and Miller, E. C., Cancer Res., 20, 950 (1960).

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    Miller, J. A., Wyatt, C. S., Miller, E. C., and Hartmann, H. A., Cancer Res., 21, 1465 (1961).

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    Smith, W. R. D., Ph.D. thesis, Univ. Nottingham (1963).

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    Elson, L. A., Brit. J. Cancer, 6, 392 (1952).

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    Andersen, R. A., Enomoto, M., Miller, J. A., and Miller, E. C., Proc. Amer. Assoc. Cancer Res., 4, 2 (1963).

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    Boyland, E., Manson, D., and Nery, R., J. Chem. Soc., 606 (1962).

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    Freese, E., Bautz-Freese, E., and Bautz, E., J. Mol. Biol., 3, 133 (1961).

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    Somers, C. E., and Hsu, T. C., Proc. U.S. Nat. Acad. Sci., 48, 937 (1962).

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  1. Cancer Research Laboratory, University of Nottingham

    • R. W. BALDWIN
    • , W. R. D. SMITH
    •  & S. J. SURTEES


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