Abstract
RECENT investigations1,2 have indicated that 2-acetyl-aminofluorene and 4-acetylaminobiphenyl are metabolized to N-hydroxy derivatives in the rat and these metabolites are more carcinogenic than the parent amides. Thus, N-hydroxy-4-acetylaminobiphenyl was as active as the parent amide as a mammary carcinogen and in addition induced a higher incidence of ear-duct carcinomata and forestomach papillomata2.
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BALDWIN, R., SMITH, W. & SURTEES, S. Carcinogenic Action of N-hydroxy-4-acetylaminostilbene. Nature 199, 613–614 (1963). https://doi.org/10.1038/199613a0
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DOI: https://doi.org/10.1038/199613a0
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