Abstract
CLASSICAL thinking holds that the bulk of urea formed in the body is derived from reactions of the Krebs–Henseleit cycle1 occurring in the liver of mammals and of amphibia2. Although the cycle is incomplete in mammalian kidney due to a relative lack of ornithine transcarbamylase and of carbamyl phosphate synthetase3, the enzymatically catalysed pathway, citrulline+aspartate⇌arginine⇌urea+ornithine provides a potential source of urea in kidney cells.
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BRODSKY, W., CARLISKY, N. Purine Catabolism, a Source of Endogenously Formed Urea in Homogenates of Amphibian Kidney. Nature 199, 602–603 (1963). https://doi.org/10.1038/199602a0
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DOI: https://doi.org/10.1038/199602a0
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