Letter | Published:

Possible Turnover of DNA with an Increased 6-Methylaminopurine Content

Naturevolume 199pages599600 (1963) | Download Citation



THE 6-methylaminopurine content of the DNA of a thymine-requiring mutant of E. coli strain 15, normally 2.1 per cent of the adenine, increases when 5-aminouracil is added to a logarithmically growing culture1. We have previously reported that the 6-methylaminopurine content of the DNA of a culture of a similar strain (strain I) continues to increase after net DNA synthesis ceases2. We have also shown that this increase could not be attributed to additions to the ends of DNA molecules since 6-methylaminopurine was not localized at these ends2.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Dunn, D. B., and Smith, J. D., Biochem. J., 68, 627 (1958).

  2. 2

    Theil, E. C., and Zamenhof, S., J. Biol. Chem. (in the press).

  3. 3

    Kornberg, A., Zimmerman, S. B., Kornberg, S. B., and Josse, J., Proc. U.S. Nat. Acad. Sci., 45, 772 (1959).

  4. 4

    Fleissner, E., and Borek, E., Proc. U.S. Nat. Acad. Sci., 48, 1199 (1962).

  5. 5

    Gold, M., Hurwitz, J., and Anders, M., Biochem. and Biophys. Res. Comm., 11, 107 (1963).

  6. 6

    Zamenhof, S., Rich, K., and De Giovanni, R., J. Biol. Chem., 234, 2960 (1959).

  7. 7

    Strauss, B. S., J. Gen. Microbiol., 30, 89 (1963).

  8. 8

    Ryan, F. J., J. Gen. Microbiol., 21, 530 (1959).

  9. 9

    Sueoka, N., and Cheng, T. Y., J. Mol. Biol., 4, 161 (1962).

  10. 10

    Zamenhof, S., in Methods in Enzymology, edit. by Colowick, S. P., and Kaplan, N. O., 3, 696 (Academic Press, New York, 1957).

Download references

Author information


  1. Department of Biochemistry, College of Physicians and Surgeons, Columbia University, New York, 32



  1. Search for ELIZABETH C. THEIL in:

  2. Search for STEPHEN ZAMENHOF in:

About this article

Publication history

Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.