Letter | Published:

Infertility in Mice caused by Nutritional Stress before Mating

Naturevolume 199pages504505 (1963) | Download Citation



MICE from which all food was withheld for 48 h from th e end of the third to the end of the fifth day after finding copulation plugs did not litter1. The fasting appeared to depress hypophyseal gonadotrophic function, causing degeneration of the deciduomata and secondary embryonic death. Although embryonic death is an important cause of infertility, failure of fertilization and death of ova before nidation are also commonly involved in the patho-genesis of mammalian infertility. This communication reports the results of attempts to influence the viability of the ovum by imposing nutritional stress before ovula-tion. As it was essential not to inhibit oestrus and mating a shorter period of starvation was given.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    McClure, T. J., J. Reprod. Fertil., 4, 241 (1962).

Download references

Author information


  1. Department of Veterinary Medicine, University of Sydney

    • T. J. McCLURE


  1. Search for T. J. McCLURE in:

About this article

Publication history

Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.