Letter | Published:

Splitting of Uracil Dimer by High-energy Electrons

Naturevolume 199page504 (1963) | Download Citation

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Abstract

THYMINE or uracil in frozen aqueous solutions are readily converted into their dimers by ultra-violet irradiation1–3. Using ion exchange chromatography on ‘Dowex 1’, the dimers of both pyrimidines-2-14C were prepared in chromatographic homogeneous forms. Kecently, it was established by us that thymine dimer is easily split into thymine monomer by irradiation with high-energy electrons4.

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References

  1. 1

    Rörsch, A., Beukers, R., Ijlstra, J., and Berends, W., Recueil. Trav. chim. Pays-Bas, 77, 423 (1958).

  2. 2

    Beukers, R., and Berends, W., Biochim. Biophys. Acta, 41, 550 (1960).

  3. 3

    Wacker, A., Träger, L., and Weinblum, D., Angew. Chemie, 73, 65 (1961).

  4. 4

    Schmidt, B., Hartmann, D., Grossgebauer, K., and Schumacher, W., Naturwiss., 50, 473 (1963).

  5. 5

    Lochmann, E.-R., Naturwiss., 50, 474 (1963).

  6. 6

    Wacker, A., Dellweg, H., and Weinblum, D., Naturwiss., 47, 477 (1960).

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Affiliations

  1. Institut für Hygiene und Medizinische Mikrobiologie, Freie Universität, Berlin

    • B. SCHMIDT
    • , D. HARTMANN
    • , K. GROSSGEBAUER
    •  & W. SCHUMACHER
  2. Abteilung für Strahlentherapie und Nuklearmedizin des Städtischen Rudolf-Virchow-Krankenhauses, Berlin

    • B. SCHMIDT
    • , D. HARTMANN
    • , K. GROSSGEBAUER
    •  & W. SCHUMACHER

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https://doi.org/10.1038/199504a0

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