Letter | Published:

Persistence of Antigen in Nucleoprotein Fractions of Mouse Spleen Cells during Antibody Formation

Naturevolume 199pages502503 (1963) | Download Citation



THE fate and distribution of antigenic determinants in immunized animals is largely unknown1. There has been much speculation and experimentation concerning persistence of antigen during the period of antibody formation, as well as possible relationship of persisting antigen to specific immunological tolerance2,3. Recent work has indicated that neonatal injections of soluble antigens derived from Shigella micro-organisms may result in specific immune unresponsiveness in young mice4,5. It was postulated that ‘excess’ antigen, analogous to pneu-mococcal polysaccharide, may persist for extended periods of time in the mouse tissues, and thus induce an unresponsiveness similar to ‘immunological paralysis’6.

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  1. Departments of Microbiology, Albert Einstein Medical Center and Temple University School of Medicine, Philadelphia



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