Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Persistence of Antigen in Nucleoprotein Fractions of Mouse Spleen Cells during Antibody Formation

Nature volume 199, pages 502–503 (1963)Cite this article

Abstract

THE fate and distribution of antigenic determinants in immunized animals is largely unknown1. There has been much speculation and experimentation concerning persistence of antigen during the period of antibody formation, as well as possible relationship of persisting antigen to specific immunological tolerance2,3. Recent work has indicated that neonatal injections of soluble antigens derived from Shigella micro-organisms may result in specific immune unresponsiveness in young mice4,5. It was postulated that ‘excess’ antigen, analogous to pneu-mococcal polysaccharide, may persist for extended periods of time in the mouse tissues, and thus induce an unresponsiveness similar to ‘immunological paralysis’6.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Haurowitz, F., Immunity and Virus Infections, 18 (Wiley, New York, 1959).

    Google Scholar 

  2. Smith, R. T., and Bridges, R. A., J. Exp. Med., 108, 627 (1958).

    Article  Google Scholar 

  3. Stavitsky, A. B., Adv. Immunol., 1, 211 (1961).

    Article  CAS  Google Scholar 

  4. Friedman, H., and Gaby, W. L., J. Immunol., 85, 478 (1960).

    CAS  PubMed  Google Scholar 

  5. Friedman, H., J. Immunol., 89, 257 (1962).

    CAS  PubMed  Google Scholar 

  6. Felton, L. D., J. Immunol., 61, 107 (1949).

    CAS  Google Scholar 

  7. Harris, S., Harris, T., Ogburn, G. A., and Farber, M. B., J. Exp. Med., 104, 656 (1956).

    Google Scholar 

  8. Schneider, W. G., and Hogebloom, G. H., Biol. Chem., 183, 123 (1950).

    CAS  Google Scholar 

  9. Mirsky, A. E., and Pollister, A. W., J. Gen. Physiol., 30, 119 (1947).

    Google Scholar 

  10. Haurowitz, F., and Crampton, C. F., J. Immunol., 68, 73 (1951).

    Google Scholar 

  11. Garvey, J. S., and Campbell, D. H., J. Exp. Med., 105, 361 (1957).

    Article  CAS  Google Scholar 

  12. Sterzl, J., and Hrubesova, M., Folia Biol., 2, 21 (1957).

    Google Scholar 

  13. Friedman, H., Fed. Proc., 18, 567 (1959).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Microbiology, Albert Einstein Medical Center and Temple University School of Medicine, Philadelphia

    H. FRIEDMAN

Authors
  1. H. FRIEDMAN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

FRIEDMAN, H. Persistence of Antigen in Nucleoprotein Fractions of Mouse Spleen Cells during Antibody Formation. Nature 199, 502–503 (1963). https://doi.org/10.1038/199502a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/199502a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing