Letter | Published:

Preparation of an Antiserum Specific to a Spontaneous Mouse Leukæmia after the Induction of Artificial Immunological Tolerance to Normal Mouse Tissue

Naturevolume 199pages501502 (1963) | Download Citation



THE feasibility of preparing antisorum to the transplantable Ehrlich ascites tumour after the induction of immunological tolerance to normal mousa tissue antigens in the neonatal rabbit has been reported previously from this laboratory1,2. Such tolerant anti-Ehrlich ascites tumour sera, when tested in vivo, were toxic for the tumour and relatively innocuous for the murine host. Non-tolerant anti-Ehrlich ascites tumour sera displayed far greater murine toxicity, and no greater, or decreased, protection against the transplanted tumour. Antisera to normal tissues from animals previously made tolerant to the same tissues have no increased anti-tumour effect, and non-tolerant anti-normal tissue sera have not only no increased anti-tumour activity, but are highly murine toxic. Other authors, using in vitro tests, have reported similar findings on other tumours3,4.

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  1. 1

    Levi, E., Schechtman, A. M., Sherins, R. S., and Tobias, S., Nature, 184, 563 (1959).

  2. 2

    Levi, E., and Schechtman, A. M., Cancer Res. (in the press).

  3. 3

    Garb, S., Stein, A. A., and Sims, G. J., Immunol., 88, 142 (1962).

  4. 4

    Sekla, B., and Holeckova, E., Acta Un. Intern. Cancer, 18, 76 (1962).

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    Present address: Department of Medicine, Mount Sinai Hospital, Los Angeles, 48, California


  1. Department of Zoology, University of California, Los Angeles, 24



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