Letter | Published:

‘Refuin’ : a Non-cytotoxic Carcinostatic Compound proliferated by a Thermophilic Actinomycete

Naturevolume 199page501 (1963) | Download Citation

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Abstract

‘REFUIN’ is a high-molecular fraction of a fermentation beer produced by a thermophilic actinomycete. The fraction is recovered by precipitation with ammonium sulphate and by fractional ice crystallization. Although the fermentation temperature is 50° C, the active principle is heat-labile, losing all activity after 6 h at room temperature. Electrophoretic analysis reveals a ninhydrin staining positively charged band.

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References

  1. 1

    Tendler, M. D., Bull. Torrey Bot. Club, 86, 17 (1959). Tendler, M. D., and Burkholder, P. R., App. Microbiol., 9, 394 (1961).

  2. 2

    Moore, George E., Symp. and Panel Disc., N.Y. State J. Med., 62, 2124 (1962).

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Affiliations

  1. Department of Biology, Yeshiva University, New York, 33

    • MOSES DAVID TENDLER
  2. Department of Neoplastic Medicine, Montefiore Hospital, Bronx, New York

    • SAMUEL KORMAN

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https://doi.org/10.1038/199501a0

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