Letter | Published:

Biomicroscopic Observations on Vasocon-strictive and Thrombogenic Effects produced by Long-chain Saturated Fatty Acids within the Vasculature of the Wing of an Unanæsthetized Bat

Naturevolume 199pages495496 (1963) | Download Citation

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Abstract

POOLE1 reported in 1955 that when certain fatty acids in low concentration are added to plasma the clotting time is shortened. In 1959 he2 modified Chandler's3 system to make and to study artificial thrombi. In 1961, with Connor4, he showed that when straight-chain saturated fatty acids with 16 or more carbon atoms were added to mixtures of blood in Chandler's system thrombus formation was accelerated and the thrombi so formed larger. Short -chain fatty acids, C6 and C7, had no activity and unsat-urated acids were inactive, or very nearly so.

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References

  1. 1

    Poole, J. C. F., Brit. J. Exp. Path., 36, 248 (1955).

  2. 2

    Poole, J. C. F., Quart. J. Exp. Physiol., 44, 377 (1959).

  3. 3

    Chandler, A. B., Lab. Invest., 7, 110 (1958).

  4. 4

    Connor, W. G., and Poole, J. C. F., Quart. J. Exp. Phys., 46, 1 (1961).

  5. 5

    Connor, W. G., Hoak, J. C., and Warner, E. D., Fed. Proc., 21, 60 (1962) (abstract).

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    Soloff, L. A., and Day, H. J., Clin. Proc. (to be published) (abstract).

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    Nicoll, P. A., and Webb, R. L., Ann. N.Y. Acad. Sci., 46, 697 (1946).

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    Duguid, J. B., J. Path. Bact., 58, 207 (1946).

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    Anitschow, N., Chalatow, S., Centrablf. allg. Path. Path. Anat., 24, 1 (1913).

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Affiliations

  1. Temple University Medical Center, Philadelphia

    • LOUIS A. SOLOFF
    •  & MARY P. WIEDEMAN

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https://doi.org/10.1038/199495a0

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