Letter | Published:

Assessment of Functional Competence in Isolated Muscular Tissues

Naturevolume 199pages494495 (1963) | Download Citation



IN order to test for functional competence in thin pieces of isolated tissue containing muscular elements, such as the skin of the rat (which contains smooth muscle and a sheet of skeletal muscle known as the panniculus carnosus)', a bath was devised in which the muscles could be excited directly or indirectly by transmural stimulation1. The response of the stimulated muscle provided a measure of functional competence in the surviving tissue. This bath and also our method of recording the pressure changes developed in it are described here.

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  1. 1

    Hellmann, K., J. Physiol. (Lond.) (in the press).

  2. 2

    Hellmann, K., Brit. J. Pharmacol. (in the press).

  3. 3

    Paton, W. D. M., J. Physiol. (Lond.), 127, 40, P (1955).

  4. 4

    Hellmann, K., J. Physiol. (Lond.), 165, 11, P (1963).

  5. 5

    Hellmann, K., J. Physiol. (Lond.) (in the press).

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  1. Chemotherapy Unit, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, W.C.2

    • , J. A. STEDMAN
    •  & D. I. DUKE


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