Abstract
Friedhoff and Van Winkle1 have reported the presence of 3,4-dimethoxyphenylethylamine in urine from 15 of 19 schizophrenic patients while there was none in urine from 14 normal subjects. Because of the clear biochemical difference between both groups and the structural resemblance of the amine with mescaline, it was considered to be important to confirm their results in a different laboratory. The urine amines were examined first according to their method; but resolution of compounds was not satisfactory on the paper chromatograms and several compounds having similar RF values interfered with the identification of 3,4-dimethoxyphenylethylamine. Therefore, an improved method was devised in order to obtain a better chromatogram of the amines.
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References
Friedhoff, A. J., and Van Winkle, E., Nature, 194, 897 (1962).
Kakimoto, Y., and Armstrong, M. D., J. Biol. Chem., 237, 208 (1962).
Armstrong, M. D., and Shaw, K. N. F., J. Biol. Chem., 225, 269 (1957).
Kety, S. S., Science, 129, 1528 (1959).
Fishman, V., and Goldenberg, H., Proc. Soc. Exp. Biol. Med., 104, 99 (1960).
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TAKESADA, M., KAKIMOTO, Y., SANO, I. et al. 3,4-Dimethoxyphenylethylamine and Other Amines in the Urine of Schizophrenic Patients. Nature 199, 203–204 (1963). https://doi.org/10.1038/199203a0
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DOI: https://doi.org/10.1038/199203a0
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