Abstract
INCUBATION of erythrocytes, from individuals having the sex-linked, inherited deficiency of glucose-6-phosphate dehydrogenase, with oxidant drugs such as acetylphenyl-hydrazine (APH) produces a drop in the level of intra-cellular reduced glutathione (GSH)1. Beutler et al.2 consider that APH itself has no effect, but modifies cell hæmoglobin to a complex, not methæmoglobin, which oxidizes GSH. Allen and Jandl3, on the other hand, have indicated that these two compounds oxidize one another, and that the APH oxidation products aid GSH oxidation.
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References
Beutler, E., Blood, 14, 103 (1959).
Beutler, E., Robson, M., and Buttenwieser, E., J. Clin. Invest., 36, 617 (1957).
Allen, D. W., and Jandl, J. H., J. Clin. Invest., 40, 454 (1961).
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Mills, G. C., J. Biol. Chem., 234, 502 (1959).
Thompson, R. H. S., and Watson, D., J. Clin. Path., 5, 25 (1952).
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BALINSKY, D., BERNSTEIN, R. Oxidation of Reduced Glutathione by Acetylphenylhydrazine, Hæmoglobin and Erythrocytes. Nature 199, 187–188 (1963). https://doi.org/10.1038/199187b0
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DOI: https://doi.org/10.1038/199187b0
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