Letter | Published:

Thyroid-adrenocortical Antagonism and Histamine Metabolism

Naturevolume 199pages12981299 (1963) | Download Citation



Bjurö, Westling and Wetterqvist1 have recently suggested that there is a direct antagonism between the actions of the adreno-corticosteroids and those of the thyroid hormones on histamine metabolism in rats. Their results were obtained, chiefly, by estimating the urinary output of histamine. We have been investigating this problem over the past two years2,3 and conclude that this action of the thyroid hormones is mediated indirectly through their effects on the level of adrenocorticosteroids in the body. Thus only the glucocorticosteroids exert a direct effect on histamine metabolism, their blood concentrations determining the level of histamine sensitivity and of other aspects of histamine metabolism.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Bjurö, T., Westling, H., and Wetterqvist, H., Nature, 196, 1213 (1962).

  2. 2

    Spencer, P. S. J., and West, G. B., Brit. J. Pharmacol., 17, 137 (1961).

  3. 3

    Spencer, P. S. J., and West, G. B., Intern. Arch. Allergy, 20, 321 (1962).

  4. 4

    Peterson, R. E., J. Clin. Invest., 37, 736 (1958).

  5. 5

    Tomkins, G. M., and mcGuire, jun., J. S., Ann. N.Y. Acad. Sci., 86, 600 (1960).

Download references

Author information

Author notes

    • P. S. J. SPENCER

    Present address: Research Division of Allen and Hanburys, Ltd., Ware, Herts


  1. Department of Pharmacology, School of Pharmacy, University of London, Brunswick Square, London, W.C.1

    • P. S. J. SPENCER
    •  & G. B. WEST


  1. Search for P. S. J. SPENCER in:

  2. Search for G. B. WEST in:

About this article

Publication history

Issue Date




By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.