Letter | Published:

Reduction by Chlorpromazine of Pylorus-ligation Ulcers in the Rat

Naturevolume 199page1296 (1963) | Download Citation

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Abstract

RECENT research indicates that chlorpromazine is an effective inhibitor of gastric secretion1–3 and reduces starvation ulcers in mice4. This investigation was undertaken to determine quantitatively the extent of ulceration in the fore-stomach and glandular stomach of the pylorus-ligated rat after treatment with chlorpromazine.

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References

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    Sun, D. C. H., and Shay, H., Amer. J. Physiol., 187, 635 (1956).

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    Sun, D. C. H., and Shay, H., Gastroenterol., 36, 245 (1959).

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    Pfeiffer, C. J., Gass, G. H., and Schwartz, C. S., Nature, 197, 1014 (1963).

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    Shay, H., Komarov, S. A., Fels, S. S., Meranze, D., Gruenstein, M., and Siplet, H., Gastroenterol., 5, 43 (1945).

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    Pfeiffer, C. J., and Gass, G. H., Canad. J. Biochem. and Physiol., 40, 1473 (1962).

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    Shay, H., Komarov, S. A., and Gruenstein, M., Arch. Surg., 59, 210 (1949).

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    Bornmann, G., Arzneimittel-Forsch., 11, 89 (1961).

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    Aron, E., Nezelof, C., and Guesle, J., Arch. Mal. App. Digest., 43, 496 (1954).

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Author information

Author notes

    • CARL J. PFEIFFER

    Present address: N.A.S.A. Ames Research Center, Moffett Field, California

  1. ROY N. TIEDE: National Science Foundation Summer Science Trainee.

Affiliations

  1. Department of Physiology, Southern Illinois University, Carbondale, Illinois

    • ROY N. TIEDE
    • , CARL J. PFEIFFER
    •  & GEORGE H. GASS

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DOI

https://doi.org/10.1038/1991296a0

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