Letter | Published:

Transient Responses of Purkinje Fibres to Non-uniform Currents

Nature volume 199, pages 12941295 (28 September 1963) | Download Citation

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Abstract

COMPARISONS between experimentally recorded responses of cardiac muscle to applied currents1–3 and responses predicted by a modified form of the Hodgkin–Huxley nerve equations4 have led to conflicting conclusions about the applicability of these equations to the cardiac cell membrane2,4,5. The existence of a negative membrane conductance in the equations means that strong enough inward currents applied uniformly to the membrane during the plateau of the action potential should initiate an all-or-nothing repolarization response. Fig. 1 shows computed responses to uniform currents.

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References

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    , and , J. Gen. Physiol., 41, 633 (1958). , and , Electrophysiology of the Heart (McGraw-Hill, New York, 1960).

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    , J. Physiol., 115, 227 (1951). Elekrophysiologie der Herzmuskelfaser (Hans Huber, Berne, 1956).

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    , Nature, 188, 495 (1960); J. Physiol., 160, 317 (1962); Proc. Intern. Cong. Physiol. Sci., (Leyden), 1, 177 (1962).

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    , Biophysics of Physiological and Pharmacological Actions, edit. by Shanes, 501 (1961); Handbook of Physiology, Sec. 2 Circ., 1, 237 (1962).

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    Modern Computing Methods, 116 (National Physical Laboratory, H.M.S.O., 1961).

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Affiliations

  1. Department of Physiology, University College, London.

    • A. E. HALL
    •  & D. NOBLE

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https://doi.org/10.1038/1991294a0

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