Abstract
COMPARISONS between experimentally recorded responses of cardiac muscle to applied currents1–3 and responses predicted by a modified form of the Hodgkin–Huxley nerve equations4 have led to conflicting conclusions about the applicability of these equations to the cardiac cell membrane2,4,5. The existence of a negative membrane conductance in the equations means that strong enough inward currents applied uniformly to the membrane during the plateau of the action potential should initiate an all-or-nothing repolarization response. Fig. 1 shows computed responses to uniform currents.
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HALL, A., NOBLE, D. Transient Responses of Purkinje Fibres to Non-uniform Currents. Nature 199, 1294–1295 (1963). https://doi.org/10.1038/1991294a0
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DOI: https://doi.org/10.1038/1991294a0
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