Letter | Published:

Isolation of Alkaloids using Ultrasonic Energy

Naturevolume 199pages12921293 (1963) | Download Citation



IN recent years ultrasonic energy has been used in the extraction of various materials from plants, animals, and micro-organisms for biochemical analysis1. The application of ultrasound has proved advantageous for the isolation of enzymes, nucleic acids, and other heat-labile substances from cells and tissues. Moreover, ultrasonic energy has been used widely for various industrial applications to facilitate the extraction of commercially important substances2. The increasing use of ultrasonic instruments in extraction processes is based on the observations that: (1) disruption of cells is rapid; (2) the extraction process is accelerated; (3) the yield of extract usually is increased; (4) the use of ultrasonic energy permits the extraction of certain materials otherwise not readily obtainable.

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    Fry, W. G., Advances Biol. Med. Phys., 4, 282 (1958).

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    Schroder, G. W., Food Eng., 25, 48 (1953). Babikov, I. O., Ultrasound and its Industrial Applications (Consultants Bureau, New York, 1960).

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    Hughes, D. E., and Nyborg, W. L., Science, 138, 108 (1962).

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    Thompson, D., and Vilbrandt, F. C., Indust. Eng. Chem., 46, 1172 (1954). Vigoureux, P., Ultrasonics (Wiley, New York, 1951).

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    Lott, J. A., thesis, Rutgers University (1961).

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    DeMaggio, A. E., J. Pharm. Sci., 50, 676 (1961). DeMaggio, A. E., and King, L. D., ibid., 50, 341 (1961).

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    Lott, J. A., and DeMaggio, A. E., Science, 139, 825 (1963).

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    United States Pharmacopeia (Mack, Rev. 16, Easton, Penn., 1960).

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    Nyborg, W. L., in Ultrasound in Biology and Medicine (A.I.B.S., Washington, D.C., 1957).

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    Head, W. F., jun., Beal, H. M., Lauter, W. M., J. Amer. Pharm. Assoc., Sci. Ed., 45, 239 (1956). Wray, P. E., and Small, L. D., ibid., 47, 823 (1958).

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  1. College of Pharmacy, Rutgers, The State University, Newark, New Jersey

    •  & JOHN A. LOTT
  2. College of Pharmacy, University of Rhode Island, Kingston, Rhode Island



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