Letter | Published:

A Lactic Dehydrogenase Elevating Agent in Association with Human Neoplasms

Naturevolume 199pages12021203 (1963) | Download Citation

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Abstract

THE observation that a variety of murine neoplasms contain a filterable agent capable of inducing a five- to ten-fold increase in plasma lactic dehydrogenase (LDH) activity within 48 h of inoculation into normal mice was reported by Riley et al.1, and confirmed by Mundy and Williams2. Subsequent papers described some of the characteristics of the LDH-elevating agent3,4, reported a 50- to 1,000-fold rise in plasma LDH and an approximate five-fold increase in anaerobic glycolysis after ‘infection’ of ‘virus-free’ tumours with the LDH-elevating agent5,6, and demonstrated elevated levels of other enzymes, in addition to LDH, in plasma from mice inoculated with this ‘virus’7,8.

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References

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    Riley, V., Lilly, F., Huerto, E., and Bardell, D., Science, 132, 545 (1960).

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    Mundy, J., and Williams, P. C., Science, 134, 834 (1961).

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    Riley, V., Huerto, E., Lilly, F., Bardell, D., Loveless, J. D., and Fitzmaurice, M. A., Proc. Amer Assoc. Cancer Res., 3, 262 (1961).

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    Henry, R. J., Chiamori, N., Golub, O. J., and Berkman, S., Amer. J. Clin. Path., 34, 381 (1960).

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    Erickson, R. J., and Morales, D. R., New England J. Med., 265, 478 (1961).

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    Yaffe, D., Cancer Res., 22, 573 (1962).

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Affiliations

  1. Department of Anatomy, University of Maryland School of Medicine, Baltimore

    • C. G. CRISPENS JUN.

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https://doi.org/10.1038/1991202a0

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