Letter | Published:

A Lactic Dehydrogenase Elevating Agent in Association with Human Neoplasms

Naturevolume 199pages12021203 (1963) | Download Citation



THE observation that a variety of murine neoplasms contain a filterable agent capable of inducing a five- to ten-fold increase in plasma lactic dehydrogenase (LDH) activity within 48 h of inoculation into normal mice was reported by Riley et al.1, and confirmed by Mundy and Williams2. Subsequent papers described some of the characteristics of the LDH-elevating agent3,4, reported a 50- to 1,000-fold rise in plasma LDH and an approximate five-fold increase in anaerobic glycolysis after ‘infection’ of ‘virus-free’ tumours with the LDH-elevating agent5,6, and demonstrated elevated levels of other enzymes, in addition to LDH, in plasma from mice inoculated with this ‘virus’7,8.

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    Riley, V., Lilly, F., Huerto, E., and Bardell, D., Science, 132, 545 (1960).

  2. 2

    Mundy, J., and Williams, P. C., Science, 134, 834 (1961).

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    Riley, V., Huerto, E., Lilly, F., Bardell, D., Loveless, J. D., and Fitzmaurice, M. A., Proc. Amer Assoc. Cancer Res., 3, 262 (1961).

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    Georgii, A., Kroth, H., and Bayerle, H., Klin. Wschr., 40, 363 (1962).

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    Riley, V., J. Gen. Physiol., 45, 614, A (1961).

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    Riley, V., Fed. Proc., 21, 87 (1962).

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    Plagemann, P. G. W., Watanabe, M., and Swim, H. E., Proc. Soc. Exp. Biol. Med., 111, 749 (1962).

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    Notkins, A. L., Greenfield, R. E., Marshall, D., and Bane, L., J. Exp. Med., 117, 185 (1963).

  9. 9

    Notkins, A. L., Berry, R. J., Moloney, J. B., and Greenfield, R. E., Nature, 193, 79 (1962).

  10. 10

    Henry, R. J., Chiamori, N., Golub, O. J., and Berkman, S., Amer. J. Clin. Path., 34, 381 (1960).

  11. 11

    Erickson, R. J., and Morales, D. R., New England J. Med., 265, 478 (1961).

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    Notkins, A. L., and Greenfield, R. E., Proc. Soc. Exp. Biol. Med., 109, 988 (1962).

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    Yaffe, D., Cancer Res., 22, 573 (1962).

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    Merker, P. C., and Woolley, G. W., Cancer Res., 19, 664 (1959).

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    Gallily, R., and Woolley, G. W., Ann. N.Y. Acad. Sci., 76, 791 (1958).

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  1. Department of Anatomy, University of Maryland School of Medicine, Baltimore



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